The Red Cross Movement began in Macau since the 1920s._ In 1922, the Movement was integrated as a branch of the Portuguese Red Cross._ The organization was formally renamed the Macau Red Cross (Branch of the Portuguese Red Cross) in 1987._ After China reclaimed sovereignty of Macau on December 20, 1999, the Macau Red Cross transitioned into a highly autonomous branch of Red Cross Society of China.

During its early stages, Macau Red Cross developed with the work and effort of a group of dedicated volunteers._ Providing financial and location support, the early staff allowed the organization to operate even without facilities such as proper office premises._ However, during the Pacific War (WWII) of the 1940s, the Macau Red Cross played a crucial role in dealing with the influx of refugees into the city._ Carrying out its primary objective of humanitarian assistance, the organization offered medication, clothing, food and shelter to the needy.

On November 5, 1990, with much-appreciated help from a local charity organization, Macau Red Cross was offered a villa with low rental at Avenida da República No.58-60 where it was used as its headquarters._ Then in 2003, the villa was completely renovated and now used as the Medical Transfer Service Center._ On May 8, 2000, Macau Red Cross set up a Secretariat office at Alameda Dr. Carlos D'Assumpção, Nos. 255-263, China Civil Plaza, 3rd Floor. In order to meet the great demands and the continuous expansion of services, Macau Red Cross decided to use these premises as its existing headquarters, and to facilitate the ongoing evolvement of the organization's humanitarian efforts in Macau and beyond.

As a member of the International Committee of the Red Cross and the International Federation of Red Cross and Red Crescent Societies, Macau Red Cross operates according to its seven fundamental principles: Humanity, Impartiality, Neutrality, Independence, Voluntary Service, Unity and Universality._ Building upon the mandate of the International Red Cross and Red Crescent Movements, Macau Red Cross strives to prevent and alleviate human suffering with its humanitarian work in Macau and beyond.

The Macau SAR Government provides most of the Macau Red Cross's funds._ Moreover, the society also receives funding from member fees and donations from various individuals and organizations in the Macau community.

The organizational structure of the Macau Red Cross is defined by the organization 's legal statute released on December 13, 1999 in the Macau Official Gazette._ According to the legal statute, the General Assembly, which holds one meeting annually, is the highest authority of the Macau Red Cross._ Between consecutive meetings, the member-selected Central Council carries the nominal duties of the Assembly._ From amongst the members, a Fiscal council is also selected to supervise the accuracy of the organization 's accounts and the legality of the operations._ In addition, a Directive Council is elected by the Central Council to administer daily operations of Macau Red Cross.¡@